Drift of the pesticide dicamba has been linked to crop damage in 25 states this year.
Monsanto steadfastly denies responsibility.
The lawsuit hopes permanent injunctions will be placed on these large companies, forcing them to stop selling and marketing their dicamba herbicide.
The Center for Biological Diversity said the new EPA decision will open the door for dicamba use to jump from less than 1 million pounds to more than 25 million annually.
Hundreds of thousands of soybean and cotton crops have been negatively impacted by the apparent misuse of the drift-prone herbicide dicamba on Monsanto’s Roundup.